Zebrafish provides a novel model for lymphatic vascular research.
Identifieur interne : 004988 ( Main/Exploration ); précédent : 004987; suivant : 004989Zebrafish provides a novel model for lymphatic vascular research.
Auteurs : Terhi Karpanen [Pays-Bas] ; Stefan Schulte-MerkerSource :
- Methods in cell biology [ 0091-679X ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Biologie du développement (), Colorants fluorescents (analyse), Danio zébré (embryologie), Danio zébré (physiologie), Humains, Imagerie accélérée (), Imagerie moléculaire (), Lymphangiogenèse (physiologie), Lymphographie (), Maladies lymphatiques (anatomopathologie), Maladies lymphatiques (génétique), Modèles animaux de maladie humaine, Métabolisme des lipides, Souris, Transduction du signal (physiologie), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (embryologie).
- MESH :
- analyse : Colorants fluorescents.
- anatomopathologie : Maladies lymphatiques, Vaisseaux lymphatiques.
- embryologie : Danio zébré, Vaisseaux lymphatiques.
- génétique : Maladies lymphatiques.
- physiologie : Danio zébré, Lymphangiogenèse, Transduction du signal.
- Animaux, Biologie du développement, Humains, Imagerie accélérée, Imagerie moléculaire, Lymphographie, Modèles animaux de maladie humaine, Métabolisme des lipides, Souris.
English descriptors
- KwdEn :
- Animals, Developmental Biology (methods), Disease Models, Animal, Fluorescent Dyes (analysis), Humans, Lipid Metabolism, Lymphangiogenesis (physiology), Lymphatic Diseases (genetics), Lymphatic Diseases (pathology), Lymphatic Vessels (embryology), Lymphatic Vessels (pathology), Lymphography (methods), Mice, Molecular Imaging (methods), Signal Transduction (physiology), Time-Lapse Imaging (methods), Zebrafish (embryology), Zebrafish (physiology).
- MESH :
- chemical , analysis : Fluorescent Dyes.
- embryology : Lymphatic Vessels, Zebrafish.
- genetics : Lymphatic Diseases.
- methods : Developmental Biology, Lymphography, Molecular Imaging, Time-Lapse Imaging.
- pathology : Lymphatic Diseases, Lymphatic Vessels.
- physiology : Lymphangiogenesis, Signal Transduction, Zebrafish.
- Animals, Disease Models, Animal, Humans, Lipid Metabolism, Mice.
Abstract
The mammalian lymphatic vasculature has an important function in the maintenance of tissue fluid homeostasis, absorption of dietary lipids, and immune surveillance. The lymphatic vessels are also recruited by many tumors as primary routes for metastasis and mediate immune responses in inflammatory diseases, whereas dysfunction of the lymphatic drainage leads to lymphedema. The characterization of a lymphatic vasculature in zebrafish has made the advantages of this small model organism, the suitability for intravital time-lapse imaging of developmental processes and the amenability for chemical and forward genetic screens, available to lymphatic vascular research. Here we review our current understanding of embryonic lymphangiogenesis in zebrafish, its molecular and anatomical similarities to mammalian lymphatic vascular development, and the possibilities zebrafish offers to complement mouse models and cell culture assays in the lymphangiogenesis field.
DOI: 10.1016/B978-0-12-381320-6.00009-6
PubMed: 21951532
Affiliations:
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KNAWand University Medical Center Utrecht, Uppsalalaan 8, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Hubrecht Institute - KNAWand University Medical Center Utrecht, Uppsalalaan 8, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name></author></analytic><series><title level="j">Methods in cell biology</title><idno type="ISSN">0091-679X</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Developmental Biology (methods)</term><term>Disease Models, Animal</term><term>Fluorescent Dyes (analysis)</term><term>Humans</term><term>Lipid Metabolism</term><term>Lymphangiogenesis (physiology)</term><term>Lymphatic Diseases (genetics)</term><term>Lymphatic Diseases (pathology)</term><term>Lymphatic Vessels (embryology)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphography (methods)</term><term>Mice</term><term>Molecular Imaging (methods)</term><term>Signal Transduction (physiology)</term><term>Time-Lapse Imaging (methods)</term><term>Zebrafish (embryology)</term><term>Zebrafish (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Biologie du développement ()</term><term>Colorants fluorescents (analyse)</term><term>Danio zébré (embryologie)</term><term>Danio zébré (physiologie)</term><term>Humains</term><term>Imagerie accélérée ()</term><term>Imagerie moléculaire ()</term><term>Lymphangiogenèse (physiologie)</term><term>Lymphographie ()</term><term>Maladies lymphatiques (anatomopathologie)</term><term>Maladies lymphatiques (génétique)</term><term>Modèles animaux de maladie humaine</term><term>Métabolisme des lipides</term><term>Souris</term><term>Transduction du signal (physiologie)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (embryologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fluorescent Dyes</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Colorants fluorescents</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies lymphatiques</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Danio zébré</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term><term>Zebrafish</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphatic Diseases</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Maladies lymphatiques</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Developmental Biology</term><term>Lymphography</term><term>Molecular Imaging</term><term>Time-Lapse Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Diseases</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Danio zébré</term><term>Lymphangiogenèse</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term><term>Signal Transduction</term><term>Zebrafish</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Lipid Metabolism</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Biologie du développement</term><term>Humains</term><term>Imagerie accélérée</term><term>Imagerie moléculaire</term><term>Lymphographie</term><term>Modèles animaux de maladie humaine</term><term>Métabolisme des lipides</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mammalian lymphatic vasculature has an important function in the maintenance of tissue fluid homeostasis, absorption of dietary lipids, and immune surveillance. The lymphatic vessels are also recruited by many tumors as primary routes for metastasis and mediate immune responses in inflammatory diseases, whereas dysfunction of the lymphatic drainage leads to lymphedema. The characterization of a lymphatic vasculature in zebrafish has made the advantages of this small model organism, the suitability for intravital time-lapse imaging of developmental processes and the amenability for chemical and forward genetic screens, available to lymphatic vascular research. Here we review our current understanding of embryonic lymphangiogenesis in zebrafish, its molecular and anatomical similarities to mammalian lymphatic vascular development, and the possibilities zebrafish offers to complement mouse models and cell culture assays in the lymphangiogenesis field.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Utrecht (province)</li></region><settlement><li>Utrecht</li></settlement></list><tree><noCountry><name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name></noCountry><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Karpanen, Terhi" sort="Karpanen, Terhi" uniqKey="Karpanen T" first="Terhi" last="Karpanen">Terhi Karpanen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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